Cpwwp2a
WebIntroduction. Diabetes mellitus is a chronic disease worldwide. According to an epidemiological survey released by the World Health Organization, the global prevalence of diabetes among adults (20–79 years) will increase from 6.4% in 2010 to 7.7% in 2030, which means that the number of affected adults will increase from 285 million to 439 million. 1 … WebDec 3, 2024 · CPWWP2A-miR-579 interaction in DR. Dysregulated functions of retinal microvasculature that comprise endothelial cells and pericytes have been reported to be a major cause of vascular leakage in patients with DR.94 An elevated expression of cPWWP2A in pericytes was reported by Liu et al. in 2024, suggesting their role in DR. …
Cpwwp2a
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WebMar 17, 2024 · The link between cPWWP2A and miR-29b was confirmed by dual-luciferase assays showing a strong binding of miR-29b to cPWWP2A (Fig. (Fig.1l). 1l). The expression of miR-29b was increased in ischemic muscle (Supplementary Fig. 9a), which was contrary to that of cPWWP2A. These results suggest that cPWWP2A is a molecular sponge for … WebOct 8, 2024 · The authors then found that cPWWP2A regulates pericyte function, pericyte-EC crosstalk, and vascular dysfunction by acting as a sponge of miR-579 and targeting …
WebA few circRNAs, such as cPWWP2A, circDNMT3B, circHIPK3, circ_0005015, et al were demonstrated to play an important role in DR by regulating the angiogenesis, proliferation, apoptosis, and inflammatory response of various cells in the retina. Conclusion: CircRNAs are involved in the development of DR. CircRNAs can not only serve as DR biomarkers ... WebMar 26, 2024 · cPWWP2A regulates retinal pericyte function and pericyte–EC crosstalk in vitro. (A and B) Pericytes were transfected with scrambled (Scr) siRNA, cPWWP2A …
WebMar 26, 2024 · Knockout of cPWWP2A and mimicking its downstream target miR579 could further increase the number of avascular zone, pericyte loss and microangioma. later, they found that overexpression of cPWWP2A ... WebDexamethasone (DEX) induces significant cytotoxicity to human osteoblasts. cPWWP2A is recently-indentified novel circular RNA (circRNA), acting as an endogenous sponge of microRNA-579 (miR-579). The present study tested the expression and potential functions of the cPWWP2A-miR-579 axis in DEX-treated osteoblasts. We show that cPWWP2A is …
WebMar 21, 2024 · Protein attributes for PWWP2A Gene. Size: 755 amino acids. Molecular mass: 81960 Da. Protein existence level: PE1. Quaternary structure: Component of a …
WebEVs enriched in cPWWP2A, with high affinity for miRNA-579, and normalized retinal microvascular function , while miRNA-202-5p-loaded EVs inhibited cell proliferation, migration, and vascularization . In rats, EVs from adipose-derived MSCs loaded with miRNA-192 relieved DR-associated inflammation and pathologic angiogenesis . basic sayings in japaneseWebIn pericytes, cPWWP2A could make miR-579 gathered to sequester its binding sites with mRNA of angiopoietin1, occludin, and sirtuin1, which led to their raised expression and the increment of cell viability, proliferation, inhibited cell apoptosis, and finally alleviated retinal microvascular permeability by targeting pericyte-EC crosstalk (Liu ... tabac du lac dijonWebMar 28, 2024 · Abstract A few studies suggested that CircRNAs were involved in the development of septic AKI. However，the role and regulation mechanism of CircRNA_35953 in septic AKI remains unclear. Here, we fou... tabac drapWebPericyte-derived cPWWP2A affects pericyte coverage and vascular integrity through interacting with miR-579 and its target genes, including angiopoietin 1/occludin/SIRT1. Our study thus reveals a critical role of cPWWP2A-mediated signaling in retinal microvascular dysfunction and implies potential therapeutic benefit with high-level expression ... taba centre jeddahWebMay 16, 2024 · For example, circRNA cPWWP2A could upregulate the expression of occludin, angiopoietin-1, and sirtuin-1 (markers regulating retinal vascularization and endothelial cell function), thereby ... tabac gazinetWebIt is shown that diabetes-related stress up-regulates cPWWP2A expression in pericytes but not in ECs, and a mechanism by which pericyte and ECs communicate is unveiled, which may offer opportunities for treating diabetic microvascular complications. Significance The crosstalk between vascular endothelial cells (ECs) and pericytes in the microvascular is … tabac gometzWebNational Center for Biotechnology Information basics asian supermarket