Webdcbld2 在神经束、血管平滑肌细胞中高度表达并在血管损伤后上调，可能涉及神经系统和血管系统中广泛类型的作用 (1,2)。研究已经发现 dcbld2 在几个类型的肺癌中上调，在转移性病灶和淋巴结转移灶中频率特别高，这提示在肿瘤进展过程和转移能力中的作用 (3)。 Web1 Apr 2024 · In addition, high expression of DCBLD2 was closely correlated with poor prognosis in primary and recurrent patients with glioblastoma. What is more, we found that knockdown of DCBLD2 notably reduced the cell proliferative, invasive and migratory capacities by elevating the expression of E-cadherin and inhibiting the expression of …
特開2024-141671 知財ポータル「IP Force」
Discoidin, CUB and LCCL domain-containing protein 2 is a protein that in humans is encoded by the DCBLD2 gene. Web5 Aug 2024 · Western blotting assays demonstrated that Dcbld2 deletion increased the PDGF signaling pathway. Biotin labeling test and membrane-cytosol separation test showed that after DCBLD2 was knocked down or knocked out, the level of PDGFR-β on the cell membrane was significantly reduced, while the amount of PDGFR-β in the cytoplasm … char1011
DCBLD2 Antibody Cell Signaling Technology
WebDiscoidin, CUB, and LCCL domain-containing protein (DCBLD)ファミリーは、2つのタイプI膜貫通型足場受容体であるDCBLD1とDCBLD2から構成されており、発育や癌において重要な役割を果たしている。非受容体チロシンキナーゼであるFYNとABLは、DCBLDファミリーメンバーの細胞内ドメイン内のYXXPモチーフのチロシン ... WebCLCP1 interacts with semaphorin 4B and regulates motility of lung cancer cells. Nagai H, Sugito N, Matsubara H, Tatematsu Y, Hida T, Sekido Y, Nagino M, Nimura Y, Takahashi T, Osada H. We previously established a highly metastatic subline, LNM35, from the NCI-H460 lung cancer cell line, and demonstrated upregulation of a novel gene, CLCP1 (CUB ... Web31 Mar 2016 · Using the yeast signal sequence trap method to isolate regulatory genes from human vascular cells, followed by RACE-PCR and genomic library screening, Kobuke et al. (2001) cloned full-length DCBLD2, which they called ESDN. The putative 775-amino acid ESDN protein contains a long signal sequence, a CUB domain, an LCCL module, a … char 0 c