Webcontrast, replacement of DnaE2 catalytic residues reproduces the dnaE2 gene deletion phenotype, strongly implying a direct role for the α-subunit in mutagenic lesion bypass. These data implicate differential protein interactions in specialist polymerase function and identify the split imuA′-imuB/dnaE2 cassette as a compelling WebNov 7, 2013 · Whilst DNA damage repair systems play a significant role in survival and adaptation of bacterial pathogens, the latter does so by provoking chronic inflammation and/or production of genotoxins, which incite DNA damage and subsequent repair in host cells. Upon infection, bacterial cell components stimulate host pathogen recognition …
DnaE2 polymerase contributes to in vivo survival and the …
WebG@ Bð% Áÿ ÿ ü€ H FFmpeg Service01w ... WebApr 18, 2003 · Although dnaE2 and recA were induced by H 2 O 2 (data not shown), the absolute induction levels were highly variable between experiments, probably due to the … santa sleigh crash 1964
dnaE2 expression promotes genetic diversity and bacterial …
WebMar 6, 2024 · DnaE2 is involved in UV tolerance as well as UV-induced mutagenesis 60 and also contributes to bacterial pathogenicity and the emergence of drug resistance (Boshoff et 61 al., 2003; Warner et al., 2010). To date, DnaE2 is the only non-replicative polymerase known to 62 contribute to chromosomal mutagenesis in mycobacteria. WebApr 15, 2024 · In the case of Caulobacter as well, catalytic mutant dnaE2* showed similar growth defects as ∆dnaE2 under MMC damage (Figure 4—figure supplement 1F). In our … santa sleigh cnc