Gata3 and breast cancer
WebMicroarray analysis of two normal and seven breast cancer samples found 129 genes with >fivefold changes. Further SAGE and EST analyses of these genes identified four … In the TCGA-BRCA cohort, tumors of 975/1085 female patients were evaluated for somatic mutations. Among these patients, a total of 103 different GATA3 mutations were identified in 138 patients (14.15%). Insertions constituted the largest type of mutations (50.5%), followed by deletions (29.1%) and substitutions … See more The median overall survival was 10.80 ± 0.7 years (11.69 ± 3.63 and 10.61 ± 2.19 years in patients without GATA3 mutation compared … See more To gain an insight into the functionality of the DEGs between normal and tumor (mutant and non-mutant) samples, gene set enrichment analysis was performed using the Metascape … See more According to the TCGA expression data, GATA3 expression level was higher in GATA3-mutant (log FC = 2.78, p = 4.38E−34 in all patients and log FC = 2.66, p = 2.07E−57 in ER … See more To gain a better understanding of the biological relationships between breast cancer-related genes, the genes that share the same GO term related to breast cancer were … See more
Gata3 and breast cancer
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WebStudies have shown that GATA3 has a critical role in the development of epithelial structures in both embryonic and adult tissues. The majority of studies regarding … WebMicroarray analysis of two normal and seven breast cancer samples found 129 genes with >fivefold changes. Further SAGE and EST analyses of these genes identified four qualified genes, ERBB2, GATA3, AGR2, and ANXA1. Their expression pattern was validated by RT-PCR in both breast cell lines and tissue samples. Loss of ANXA1 in breast cancer was ...
WebDec 15, 2005 · GATA binding protein 3 (GATA3), a transcriptional activator, emerged as one of the top genes with low expression in the meta-signature. In breast cancer, high GATA3 mRNA levels are seen in the luminal A … Web21 hours ago · GATA3 is a transcription factor that is frequently mutated in breast cancers. Dr. Takaku’s group has developed a novel assay to investigate GATA3 functions and the …
WebJun 1, 2009 · GATA3 expression inhibits breast tumor outgrowth and spontaneous lung metastasis. To test the hypothesis that GATA3 can negatively regulate the ability of … Web14 GATA3 expression seems to be more extensive in lower grade tumors and positive cases, and cases with high expression may have a better survival 14,15 However, none of those studies have assessed the specificity of GATA3 for breast cancer. In another study, strong expression of GATA3 (in >50% tumor cells) was detected only in mammary (94% ...
Web21 hours ago · GATA3 is a transcription factor that is frequently mutated in breast cancers. Dr. Takaku’s group has developed a novel assay to investigate GATA3 functions and the mechanisms through which...
WebJan 1, 2015 · GATA3 is a highly conserved, essential transcription factor expressed in a number of tissues, including the mammary gland. GATA3 expression is required for normal development of the mammary gland where it is estimated to be the most abundant transcription factor in luminal epithelial cells. In breast cancer, GATA3 expression is … china big dam projectWebNov 6, 2024 · The few ER − PR + tumors did not express CAXII or the other luminal markers FOXA1 and GATA3. Overall, CAXII is a luminal marker that can help interpret ER status in single ER/PR positive tumors. Keywords: breast cancer; luminal tumors; ERα; PR; CA12/CAXII; GATA3; estrogen signaling; ER status; immunostaining Graphical Abstract … china bike graveyardWebGATA3 is one of the three genes mutated in >10% of breast cancers (Cancer Genome Atlas). [29] Studies in mice indicate that the gene is critical for the normal development of … china broadnet中文WebGATA3 in particular is necessary for mammary gland maturation, and its loss has been implicated in breast cancer development. Our goal was to validate the ability of GATA3 … china bri projectsWebGATA3 is a member of a family of zinc-finger transcription factors present in vertebrate organisms and involved in the differentiation of breast epithelia, urothelia, and a subset … china blue jean denimWebJan 10, 2015 · TMAs were stained with SOX10, GATA3, GCDFP-15, and mammaglobin. Each stain was scored by the percent positive cells (0%, negative; <10%, focal; 10%-70%, patchy; >70%, diffuse) and intensity (weak, moderate or strong). >10% staining in tumor cells was considered positive. china broadnet是什么WebThe GATA3 expression was closely associated with tumor size as well as metastasis. GATA3 significantly suppressed OS cells proliferation, migration and invasion. EMT-associated transcript factor, slug, was transcriptionally inhibited by GATA3, thereby regulation of EMT in OS.Conclusion: GATA3 serves as a tumor suppressor in OS and … china broadnet什么网络