Web25 jun. 2024 · Hypernatremia is not benign: Hypernatremia causes profound thirst. Particularly among intubated patients, this may cause misery and agitation (which may be inappropriately treated with sedatives or antipsychotics). Hypernatremia may cause delirium, thereby increasing the length of ventilation and ICU stay. Webhyperchloraemia results in acidosis when there is a concomitant reduction in the SID (strong ion difference) If is unchanged, then hyperchloraemia will not result in an acidosis thus chloride must be interpreted in the context of other strong ions, especially sodium – if sodium increases to the same extent as chloride, then SID is unchanged
Saline versus 5% dextrose in water as a drug diluent for critically ill ...
http://blog.clinicalmonster.com/2024/04/19/fluid-choice-make-difference-dka/ Webemphasizes the importance of hyperchloremia in reducing the strong-ion difference, with the consequent impairment of homeostatic mechanisms, including coagulation abnormalities and renal hypoperfusion. Pathophysiology Debate continues about the exact mechanism for acid-base homeostasis in humans. The two main camps in the dispute follow tatuaggi t2
0.9% NaCl vs. Ringer
Web27 jul. 2024 · The incidence of base deficit in excess of −2 mEq/L was compared between NS and LR and between NS and NR using tests of independent proportions. In a pilot study enrolling 48 patients, we found that the incidence of base deficit in excess of −2 mEq/L was 15%. This study was originally powered to detect a difference in the incidence of 25% ... WebUpon study completion, the NS group had a significant hyperchloremia (119 ± 1.9 mEq/L versus 105 ± 2.9 mEq/L, p < 0.01) with acidosis (7.28 ± 0.12 versus 7.45 ± 0.06, p < 0.01) in comparison to the LR group. In addition, resuscitation with NS resulted in significantly lower fibrinogen levels (99 ± 21 mg/dL versus 123 ± 20 mg/dL, p = 0.02 Web12 jun. 2024 · Balanced fluids are more similar to plasma and contain precursors to bicarbonate, but LR contains calcium that limits compatibility with blood and medication. Although balanced fluids contain potassium, they are unlikely to cause or worsen hyperkalemia. Normal saline causes a hyperchloremic metabolic acidosis and potentially … tatuaggi sum 41