Phenotype harmonization
WebAug 24, 2024 · Phenotype harmonization and cross-study collaboration in GWAS . consortia: the GENEVA experience. Genet Epidemiol. 35(3):159–173. Brunkwall L, Jönsson D, Ericson U, Hellstrand S, Kennbäck C ... WebPhenotype Working Groups. For each phenotype category of interest, the Response Phenotype Harmonization Subcommittee is convening a Working Group, led by an investigator from one of the studies, to identify and define specific variables to be shared in cross-study analyses. GARNET Contacts: Ebony B. Madden, Ph.D., M.G.C.
Phenotype harmonization
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WebFeb 19, 2024 · Introduction. The All Of Us Research Program, previously called the Precision Medicine Initiative, is a massive national undertaking to build a cohort of one million patients, who will have consented to allow access to their healthcare and genetic data for research [].The premise is that giving researchers access to both phenotype and genotype … WebApr 13, 2024 · At that time I had been working as part of the phenotype harmonization team. I was gaining experience working with phenotype data, including how we were categorizing and harmonizing race and ethnicity. ... helping with content, and editing. My area of focus was the harmonization section since that was what I had experience with at work ...
WebAs an illustration of the use of data-driven traits across multiple cohorts, we present an application of dental caries experience data harmonization in 8 participating studies ( N = 55,143) using previously developed permanent dentition tooth … WebOct 28, 2024 · The TOPMed DCC’s phenotype harmonization efforts are described under DCC-harmonized phenotypes for the scientific community, along with a phenotype tagging project that can assist members of the scientific community in finding related phenotype variables to perform their own harmonizations.
WebPhenotype harmonization requires identifying common phenotypes, determining the feasibility of cross-study analysis for each, preparing common definitions, and applying …
WebJun 20, 2024 · The harmonized phenotype data and associated documentation have been submitted to National Institutes of Health data repositories for controlled-access by the scientific community. We also provide ...
WebAlzheimer's Disease Sequencing Project Phenotype Harmonization Consortium Alzheimer's Disease Sequencing Project Phenotype Harmonization Consortium Details History Project Number 1U24AG074855-01 Agency/Funding Organization NIA Funding Year 2024 View Full Project Details for Alzheimer's Disease Sequencing Project Phenotype Harmonization … lauren lurkinsWebDec 10, 2024 · The results indicate that model-based harmonization for the study of complex traits is a useful step within genetic consortia. Parallel meta-analysis is a popular approach for increasing the power to detect genetic effects in genome-wide association studies across multiple cohorts. Consortia studying the genetics of behavioral … lauren luongo photosWebBy coordinating genotyping and phenotype harmonization across groups, PAGE is defining the epidemiological architecture of cross-population allele frequencies, relative risks, and distribution of phenotypes associated with particular variants and their environmental modifiers. Investigators Page II Study Investigators lauren luppinoWebthe interaction of genotype and phenotype. This is a large repository that includes genome-wide associa-tion studies (GWAS), medical sequencing, molecu-lar diagnostic assays, as well as association between genotype and non-clinical traits. Genetic studies funded by the National Institutes of Health (NIH) over a certain size are required to ... lauren lupkinWebThe individual predictive performance of each clinical variable, as well as the imaging phenotype based on harmonized (i.e., Phenotype (ComBat)) and non-harmonized (i.e., Phenotype (non-ComBat)) features, were assessed by fitting a Cox proportional hazards regression model and then estimating the C-score associated with the fitted models. lauren lutzkoWebAug 24, 2024 · The overarching approach for phenotype harmonization in GLIDE2 is 3-tiered . We begin by considering a broad definition of disease versus health (i.e., 1 or more decayed, missing, filled teeth or surfaces, DMFT/DMFS >0) to allow for the inclusion of the maximum number of participants from all contributing studies. lauren lutostanskiWebThe first data freeze for the Alzheimer’s Disease Sequencing Project Phenotype Harmonization Consortium (ADSP-PHC) was released in 2024. The project's scope … lauren lupus