Phf21a
WebThe PHF21A (PHD finger protein 21A gene, OMIM*608325) encodes BHC80, a compo-nent of a BRAF35/histone deacetylase (HDAC) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) [1]. It is involved in the regulation of neuronal WebFeb 1, 2024 · PHF21A is genetically associated with Potocki–Shaffer Syndrome, but the molecular basis of cognitive deficits is unknown.. RNA-Seq of PHF21A-deficient patient cells revealed 1,885 commonly misregulated genes.. Pathway analysis showed downregulation of pathways relevant to learning and memory, including cAMP-mediated signaling. • Reporter …
Phf21a
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WebPHF21A expression in 201 liver cancer samples and 129 adjacent normal tissues was detected by immunohistochemistry. The correlation between PHF21A expression and the … WebFeb 5, 2024 · PHF21A is involved in autism spectrum disorder and intellectual disability, and its haploinsufficiency causes a diverse neurological phenotype. PHF21A truncating …
WebOct 26, 2024 · PHF21A PHD finger protein 21A. PHF21A. PHD finger protein 21A. Gene ID: 51317, updated on 26-Oct-2024. Gene type: protein coding. Also known as: BHC80; NEDMS; BM-006; IDDBCS. See all available tests in GTR for this gene. Go to complete Gene record for PHF21A. Go to Variation Viewer for PHF21A variants. PHD finger protein 21A is a protein that in humans is encoded by the PHF21A gene.
WebPHF21A; see all. Function. Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it ... WebThe PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron …
WebPrEST Antigen PHF21A [Catalog No.: ATL-APrEST76038] Toggle menu. Compare ; Phone: 760-431-4600 / Fax: 760-431-4604; Sign in or Register; Cart 0. Search. CURRENT …
WebOct 22, 2024 · Deleterious nonsense, frameshift, and missense mutations disrupting the AT Hook domain and/or an intrinsically disordered region in PHF21A were found to be … bw州 ドイツWebOct 22, 2024 · PHF21A has been associated with intellectual disability and craniofacial anomalies based on its deletion in the Potocki-Shaffer syndrome region at 11p11.2 and its … bw 廃人ロードbw 御三家 おすすめWebNov 27, 2024 · PHF21A encodes a protein that is part of a massive complex that binds to DNA. The gene’s exact function is unknown, but studies suggest it prevents neuron … bw 強敵トレーナーWebSep 25, 2013 · Labile Zn fingers (Zfs) in proteins contain Zn-bound thiolates that can react with electrophilic agents, causing Zn(2+) ejection and protein unfolding. Such labile Zfs have been shown to be Cys4 or Cys3His cores whose Zn-bound Cys have no hydrogen bonds. Our aim here is to identify labile Zfs in pro … bw 強いポケモンWebDec 17, 2024 · PHF21A(PHD finger protein 21A) gene, located in the short arm of chromosome 11, encodes for BHC80, a component of the Lysine Specific Demethylase 1, Corepressor of REST (LSD1-CoREST) complex. BHC80 is mainly expressed in the human fetal brain and skeletal muscle and acts as a modulator of several neuronal genes during … bw 強ポケWebPHF21A (PHD finger protein 21A) is a component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. bw 忘れおやじ