Web22 Nov 2024 · Hyperuricemia was induced by oral administration of potassium oxonate (PO) and hypoxanthine to mice for 7 days. The biochemical index results showed that treatments with low, medium, and high doses of IRh (50, 100, and 150 mg kg −1) significantly reduced serum UA levels and inhibited XOD activity in serum and in the liver. WebLipidomics study of the therapeutic mechanism of Plantaginis Semen in potassium oxonate-induced hyperuricemia rat. ... Lipidomics coupled with pathway analysis characterizes serum metabolic changes in response to potassium oxonate induced hyperuricemic rats.
In vitro antioxidant and in vivo xanthine oxidase inhibitory …
Web11 Nov 2024 · This study was aimed to evaluate the effect of astaxanthin (ASX) on hyperuricemia and kidney inflammation in potassium oxonate (PO) and hypoxanthine … Web10 Feb 2024 · Group 2; positive hyperuricemic group (HU), received potassium oxonate (PO) intraperitoneally (250 mg/kg bw, once a day at 8:00 am). The dosages of PO and timing were determined as stated above [ 19 ]. Time of administration was fixed to avoid noctorinal and diurnal changes in biochemical measurements. osu head baseball coach
Creation of an adequate animal model of hyperuricemia …
WebPolydatin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation by inhibiting NF-κB/NLRP3 inflammasome activation via the AMPK/SIRT1 pathway Lvyi Chen *a and Zhou Lan b Author affiliations Abstract This study was designed to investigate the effects of polydatin (PLD) on potassium oxonate-induced hyperuricemic rats. WebThe metabolic disease hyperuricemia (HUA) is characterized by a disturbance in purine metabolism. Peptides, such as marine fish-derived peptides, have previously been shown … WebThe effects and possible molecular mechanisms of astilbin on potassium oxonate-induced hyperuricemia mice were investigated in this study. Different dosages of astilbin (5, 10, … rock candy mechanical keyboard