2024 Pttg1 and p53

Pttg1 and p53

Author: mzvh

August undefined, 2024

WebAug 12, 2015 · Pituitary tumor-transforming gene-1 (PTTG1) was isolated from rat pituitary tumor cells in 1997 . As a vertebrate ... b Signaling network analysis of 662 differentially expressed genes revealed a network involve p53 and CTNNB1. c PTTG1 regulates DKK1 expression. HCT116 cells were transfected with pcDNA3.1 and negative control siRNA … WebNov 21, 2012 · Human pituitary tumor transforming gene-1 (PTTG1) is a novel oncogene. ... PTTG1 staining was one of the histological features (numerous mitoses, high Ki-67 index, and nuclear labelling of PTTG1 and P53) distinguishing aggressive–invasive PRL tumors from those behaving less aggressively ...

Adenovirus‐mediated transfer of siRNA against PTTG1 inhibits liver …

WebJul 28, 2024 · Pituitary tumor-transforming gene 1 (PTTG1) has been identified as an oncogene and is overexpressed in many tumor types. However, the role of PTTG1 in glioblastoma (GBM) has not been well characterized, especially in relation to angiogenesis, migration, and invasion. ... VEGF, MMP2, MMP9, MMP14, p53, p21 and cyclin D1. Pearson … WebOct 6, 2015 · In our hands, p53 transcriptionally activated the expression of these miRNAs in pituitary tumor cells. Finally, we found that PTTG1 could inhibit p53 transcriptional activity to the four miRNAs. These data indicate the existence of a feedback loop between PTTG1 targeting miRNAs, PTTG1 and p53 that promotes pituitary tumorigenesis. proxemics in china

Figure 4 Pituitary tumor-transforming gene 1 protein …

WebDec 25, 2024 · Nnegative pituitary tumor-transforming gene 1 protein-interacting protein (PTTG1IP) immunoexpression predicted a 1.5-fold risk of breast cancer death. ... protooncogene PBF is a negative regulator of p53 function in thyroid tumorigenesis, in which PBF is generally overexpressed and p53 mutations are rare compared with other tumor … WebSep 26, 2024 · pituitary tumor-transforming gene 1 protein-interacting protein, PTTG-binding factor, pituitary tumor-transforming gene protein-binding factor GeneRIFs: Gene References Into Functions protooncogene PBF is a negative regulator of p53 function in thyroid tumorigenesis, in which PBF is generally overexpressed and p53 mutations are … WebNov 18, 2014 · A well-described example is the human securin pituitary tumor-transforming gene 1 (PTTG1) which is a marker for invasive colorectal carcinoma 14 and was identified as a key signature gene associated with tumor metastasis 15. The functional interaction between PTTG1 and p53 has been demonstrated in transformed cells 16, 17. proxemics in architecture examples

PTTG: an important target gene for ovarian cancer therapy

[Pituitary tumor transforming gene 1 (PTTG1) is highly ... - PubMed

WebAug 17, 2011 · Cell lines and reagents. HCT116 is a human colon carcinoma cell line, expressing wild-type p53 and PTTG1 genes, and HCT116 p53 −/− and HCT116 PTTG1 −/− cell lines were derived using homologous recombination to knock out p53 or PTTG1 respectively , .Cells were cultured in McCoy's 5A medium containing 15% FBS. WebObjective To analyze the expression of pituitary tumor transforming gene 1 (PTTG1) in hepatocellular carcinoma (HCC) and its clinical prognostic implication. ... p53 signaling pathway and human T-lymphotropic virus (HTLV) infection. PTTG1 and its co-expressed genes were mutated to some extent in HCC, and significantly shortened OS and DFS in ... proxemics in a sentence dramaWebApr 20, 2006 · To this end, we examined the effect of PTTG1 depletion on endogenous levels of p53 and p21. p21 is one of many genes to be induced by p53 and functions as a cyclin-dependent kinase inhibitor, which induces in cell-cycle arrest at G1 phase. 34 p53 level was not markedly affected by PTTG1 depletion, but p21 level was increased in a viral … restaurants the spot randwick nsw

"WebSep 23, 2002 · a, Schematic diagram of human p53 and the shorter PTTG1-interacting TP53 cDNA. The structure of p53 is shown, including the transactivation domain (TA), DNA-binding domain (DB), tetramerization ... " - Pttg1 and p53

Pttg1 and p53

PTTG1 PTTG1 regulator of sister chromatid separation, …

Webp53 dysfunction has previously been shown to activate PPP and contribute to the Warburg effect. ... Molina-Jimenez F, Benedicto I, Murata M, et al. Expression of pituitary tumor-transforming gene 1 (PTTG1)/securin in hepatitis B virus (HBV)-associated liver diseases: evidence for an HBV X protein-mediated inhibition of PTTG1 ubiquitination and ... WebFeb 24, 2024 · Pituitary tumor-transforming gene-1 (PTTG1), one type of DNA repair-related gene, has been reported to be dysregulated in several tumors and serve as a tumor promotor. Previously, the oncogenic roles of PTTG1 were also reported in lung adenocarcinoma (LUAD). However, the prognostic values of PTTG1 in LUAD and the …

Did you know?

WebFeb 1, 2011 · The expressions of Caspase-3, Bax, p21 and p53 in HepG2 and SMMC-7721 cells were significantly increased after siRNA knockdown of PTTG1 expression. In conclusion, the PTTG1 gene is up-regulated in the cancerous tissue from patients with HCC and involved in the progression of HCC. WebPituitary tumor-transforming gene-1 (PTTG1) is a transforming gene first discovered in rat pituitary tumor cells. ... PTTG1 induces fibroblast growth factor 2 expression and promotes tumor angiogenesis.It binds to and inhibits p53 transcriptional activity. PTTG1 activates cyclin D3 and represses p21 expression, indicating a role in cell cycle ...

WebSep 23, 2002 · a, Schematic diagram of human p53 and the shorter PTTG1-interacting TP53 cDNA. The structure of p53 is shown, including the transactivation domain (TA), DNA-binding domain (DB), tetramerization ... WebJul 24, 2024 · PTTG1 may also block p53 and regulate DNA repair mechanisms and apoptosis (Hornig et al., 2002). Our group has assessed a cohort of HTLV-1 asymptomatic carriers with the goal of finding clinical and molecular aspects related to ATL progression ( Sanabani et al., 2012 ; Pessoa et al., 2014 ; de Souza et al., 2024 ).

WebPituitary tumor-transforming gene 1 protein (PTTG1) immunostaining and P53 expression. Source publication Upregulation of PTTG1 is associated with poor prognosis in prostate cancer WebAs PTTG1 (pituitary tumor transforming gene) abundance correlates with adverse outcomes in cancer treatment, we determined mechanisms underlying this observation by assessing the role of PTTG1 in regulating cell response to anti-neoplastic drugs. ... Binding of Sp1, p53 and p300 to the p21 promoter was enhanced in PTTG1(-/-) cells after ...

WebJul 28, 2008 · Pituitary tumor transforming gene 1 (PTTG1), a transforming gene highly expressed in several cancers, is a mammalian securin protein regulating both G1/S and G2/M phases. ... PTTG1 inhibits p53 ...

WebJul 16, 2010 · Significantly, the PTTG1-induced senescence is p53-dependent and telomerase-independent, which is distinctively different from that of replicative senescence. The mechanism of PTTG1-induced senescence was also analyzed. Consistent with its role in regulating sister-chromatid separation, overexpression of PTTG1 inhibited the … proxemics doorsWebAug 23, 2024 · The p53 Signaling PCR array includes 24 genes involved in cell cycle regulation. Results indicate that nine of these genes were significantly altered in FLT samples. ... PTTG1 (Pituitary tumor-transforming gene 1) regulates the cell cycle by inducing cyclin D3 and repressing p21 expression . proxemics in healthcareWebOct 20, 2008 · They also observed apoptosis by PTTG1 in p53-negative MG-63 cells. The transient or stable expressions of PTTG1 in these cells were found to increase the frequency of aneuploidy. ... Puri R, Tousson A, Chen L, Kakar SS: Molecular cloning of pituitary tumor transforming gene 1 from ovarian tumors and its expression in tumors. Cancer Lett 2001 ... restaurants tholey und umgebungWebJul 8, 2004 · PTTG upregulates expression of p53 in HEK293 and MCF-7 cells. To determine the relationship between PTTG and p53, we first determined the effect of overexpression of PTTG on p53 expression. For this purpose, we used three different cell lines. Two of these HEK293, which is a human embryonic kidney cell line, and MCF-7, which is a human … restaurants thickwood fort mcmurrayWebNov 1, 2009 · PTTG1–p53 interaction was then demonstrated by phage display assay (Bernal et al. 2002). The assay indicated that PTTG1 interacts with a p53 fragment containing residues 109–374. Glutathione S-transferase (GST) pull-down assay indicates that residues (aa 300–374) of p53 and residues (aa 66–99) of PTTG1 are important for … proxemics in filipinoWebFeb 25, 2024 · Pituitary tumor-transforming gene 1 (PTTG1) encodes a multifunctional protein that is involved in many cellular processes. However, the potential role of PTTG1 in tumor formation and its prognostic function in human pan-cancer is still unknown. ... Moreover, the UBE2C-mediated P53 ubiquitination could be a potential target in LIHC … restaurants thira santoriniWebOn the other hand, PTTG1 is a p53 target gene, and p53 inhibits NF-Y binding to the PTTG1 promoter and thus inhibits PTTG expression [226, 227]. Alternatively, p53 inhibits PTTG expression by ... proxemics in france