WebThe molecular chaperone Hsp90 plays an important role in cancer cell survival and proliferation by regulating the maturation and stabilization of numerous oncogenic proteins. Due to its potential to simultaneously disable … WebPolymeric PAC extracted from these by-products not only could be used as a source of H. pylori urease inhibitors but also as starting material for the semi-synthesis of new compounds. For instance, various low-molecular derivatives from PACs can be easily synthesized via nucleophilic attack with phenols such as phloroglucinol, resorcinol, …
Altmetric – Resorcinol-Based Grp94-Selective Inhibitors
WebSep 1, 2024 · Request PDF Resorcinol-Based Grp94-Selective Inhibitors Glucose regulated protein 94 (Grp94) is the endoplasmic reticulum resident of the 90 kDa heat … WebSep 1, 2024 · Subpocket S1 has been utilized previously for the development of Grp94-selective inhibitors as evidenced by the rational design of BnIm and its subsequent … shannade clermont
کتابخانه دیجیتال دانشگاه علوم توانبخشی و سلامت اجتماعی: Resorcinol ...
WebOct 14, 2024 · Design and synthesis of Grp94 selective inhibitors based on Phe199 induced fit mechanism and their anti-inflammatory effects Shicheng Xu a, b,1, Anping Guo a, b,1, … WebTitle: Resorcinol-Based Grp94-Selective Inhibitors: Authors: Khandelwal, Anuj;Crowley, Vincent M.;Blagg, Brian S. J.: Year: 1-Sep-2024: Publisher: American Chemical Society: … WebThe first resorcinol-based Grp94-selective inhibitor to take advantage of the hydrophobic S2 subpocket has been developed and shown to manifest low nanomolar affinity and ∼10 … shanna deloatch