Thiophene is a heterocyclic compound with the formula C4H4S. Consisting of a planar five-membered ring, it is aromatic as indicated by its extensive substitution reactions. It is a colorless liquid with a benzene-like odor. In most of its reactions, it resembles benzene. Compounds analogous to thiophene include … See more Thiophene was discovered as a contaminant in benzene. It was observed that isatin (an indole) forms a blue dye if it is mixed with sulfuric acid and crude benzene. The formation of the blue indophenin had long … See more At room temperature, thiophene is a colorless liquid with a mildly pleasant odor reminiscent of benzene, with which thiophene shares some similarities. The high reactivity of … See more • Some Thiophenes • Thieno[3,2-b]thiophene, one of the four thienothiophenes. See more • International Chemical Safety Card 1190 • Chisholm, Hugh, ed. (1911). "Thiophen" . Encyclopædia Britannica. Vol. 26 (11th ed.). Cambridge … See more Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. The first synthesis of thiophene by Meyer, reported the same year that he made his discovery, involves acetylene and … See more Thiophene is considered to be aromatic, although theoretical calculations suggest that the degree of aromaticity is less than that of benzene. The … See more Thiophenes are important heterocyclic compounds that are widely used as building blocks in many agrochemicals and … See more WebThe reaction of 2,5-dichlorothiophene with TMPMgCl•LiCl provides the 3-metalated-thiophene. This is followed by trapping with a variety of electrophiles and subsequent …
Benzothiophene synthesis - Organic Chemistry
WebMay 31, 2007 · A solution of 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid methyl ester 1 (5.0g, 0.025mol) and 2-hydroxynaphthaldehyde 2 (4.3g, 0.025 mol) in absolute ethanol (100 mL) was heated under reflux for 5 hrs. Cooling the mixture, ... WebThe reaction of the thiophene-fused cyclopentadienyl–K ((Me 3 C 7 H 2 S) − K +) with 21 in THF afforded the target compound 22 in 90% yield. The 1 H NMR spectrum of 22 was too complicated to be clearly assigned due to the presence of three chiral centers . The metalation of 22 gave the target ansa-metallocene complex 23 in 92% yield. leeds v newcastle on tv
Synthesis, properties and biological activity of thiophene: …
WebAug 23, 2014 · The oxidation of thiophenes to various thiophene 1-oxides and thiophene 1,1-dioxides and the Diels–Alder reactions of these oxides are reviewed. Progress on partial and complete reduction of ... WebIodine-catalyzed cascade reactions of substituted thiophenols with alkynes under metal- and solvent-free conditions enable the synthesis of benzothiophene derivatives in good yields. … WebFuran, thiophene, and pyrrole, like benzene and naphthalene, undergo electrophilic aromatic substitution reactions. Let’s try to predict the ring carbon at which substitution occurs in … leeds vs arsenal player ratings